Understanding which of these characteristics contribute most to a more severe course of illness may lead to a better understanding of factors contributing to the functional outcome in patients with BD, thereby revealing options for early intervention and prevention. In combining all clinical characteristics, a multifold clinical profile emerges which varies to a large degree between patients. These factors appear to be interrelated in various ways for example, an earlier onset of BD is associated with an increased rate of substance use disorders. Have all been hypothesized to be associated with a higher likelihood of developing BD or a worse outcome. The clinical manifestation and course of bipolar disorder (BD) may be influenced by several patient characteristics.
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